summary: Researchers say that getting six hours or less of sleep at the time of vaccination lowers the body’s antibody response.
The degree of vaccine protection, which may depend on getting enough sleep before and after vaccination, found a new meta-analysis examining the relationship between sleep duration and the body’s response to vaccination.
A multicenter study published March 13 found that getting less than 6 hours of sleep per night before and after vaccination was associated with significantly reduced antibody responses. biology todayAdults are generally recommended to get 7-9 hours of sleep per night.
A meta-analysis included data on the association between sleep duration and antibody responses to influenza and hepatitis vaccines. Although comparable data on COVID-19 vaccination were not available, the researchers noted that their study suggests that adequate sleep, etc., can improve responses to COVID-19 vaccination during the ongoing pandemic. stressed the need to identify simple behavioral interventions for
The weakened antibody response in those who slept poorly was very severe and was similar to the decline in COVID-19 antibodies two months after vaccination with Pfizer-Biontech or Moderna injections.
“Although we have previously found that cognitive-behavioral therapy, like mindfulness, reliably improves insomnia and normalizes various aspects of immunity, it remains to be seen whether insomnia treatment can enhance vaccination responses. We don’t know yet.” Author and director of the Cousins Center for Psychoneuroimmunology at the Jane and Terry Semmel Institute for Neuroscience and Human Behavior at UCLA.
Researchers looked at the data by gender because women typically respond more strongly to vaccination than men. There was a strong association between sleep duration and antibody response in men, but more so in women because the study did not control for fluctuations in sex hormone levels, which are known to affect immune function. data are needed, they said.
Larger studies are also needed to determine when people should get enough sleep to promote optimal vaccine responses before and after vaccination, the researchers said.
Additional authors include Karine Spiegel, Amandine E. Rey, Anne Cheylus, Kirean Ayling, Christian Benedict, Tanja Lange, Aric A. Prather, Daniel J. Taylor, and Eve Van Cauter. The authors declared no competing interests directly relevant to this study.
About this sleep and vaccine research news
author: Jason Millman
contact: Jason Millman – UCLA
image: image is public domain
Original research: open access.
“Meta-analysis of association between insufficient sleep duration and antibody response to vaccinationMichael Irwin and others biology today
Meta-analysis of association between insufficient sleep duration and antibody response to vaccination
- Lack of sleep (less than 6 hours per night) before and after vaccination reduces antibody response
- This decline is similar to the 2-month decline in antibodies from the COVID-19 vaccine.
- This association appears to be strong in men, but more data are needed in women
- Optimizing sleep duration before and after vaccination may boost antibody responses
Vaccination is a major strategy for controlling viral pandemics. Simple behavioral interventions that might enhance vaccine responses have not yet been identified. We conducted a meta-analysis to summarize the evidence linking sleep duration before and after vaccination to antibody responses in healthy adults.
The authors of the included studies accurately estimated pooled effect sizes (ES) and 95% confidence intervals (95% CI) and provided the information necessary to examine sex differences.
The association between self-reported short sleep (less than 6 hours per night) and reduced vaccine response did not reach pre-defined statistical significance (total n = 504, age 18-85 years). , the overall ES [95% CI] = 0.29 [−0.04, 0.63]).
Objectively assessed short sleep duration was associated with significantly reduced antibody responses (total n = 304, ages 18–60 years, overall ES [95% CI] = 0.79 [0.40, 1.18]). Males had greater pooled ES (total ES [95% CI] = 0.93 [0.54, 1.33]), but did not reach significance in females (overall ES [95% CI] = 0.42 [−0.49, 1.32]).
These results provide evidence that inadequate sleep duration significantly reduces the response to antiviral vaccination, and that achieving an adequate amount of sleep during the day before and after vaccination enhances the humoral response. and may be extended.
(1) the pre- and post-inoculation timeframes in which optimizing sleep duration is most beneficial, (2) the sources of gender differences in the effect of sleep on responses, and (3) the amount of sleep required to protect responses.