A groundbreaking new approach dramatically increases the sensitivity and accuracy of mass spectrometry applications in proteomics and other fields while achieving unparalleled throughput.
Chadds Ford, Pennsylvania, October 21, 2024 /PRNewswire/ — Mobilion Systems Co., Ltd.The company, a leader in separation science innovation, today announced a complex technology that is poised to disrupt the mass spectrometry industry by delivering unparalleled speed, sensitivity, specificity, and quantitative accuracy to proteomics, lipidomics, and metabolomics workflows. Presented a next-generation approach for sample analysis. In a comprehensive white paper titled “Abandoning the quadrupole for mass spectrometry fragmentation analysisMOBILion leverages the innovative features of a unique structure in lossless ion manipulation (SLIM)-based high-resolution ion mobility (HRIM) technology to enable fragmentation analysis at unprecedented speeds, increasing throughput by 5x and how low-abundance detection can be enabled. Generates signals with nearly 100% ion utilization efficiency, providing unparalleled accuracy in identifying complex biomolecules.
“This is a pivotal development for MOBILion, which we have strived for since its inception. By replacing slow, inefficient, and lossy quadrupole separation with high-resolution mobility separation, we can achieve unparalleled speed and peak capacity and represents a paradigm shift in mass spectrometry that will redefine the industry for decades to come and open the door to uncharted scientific discoveries across countless fields. melissa shermanDr. MOBILion Systems CEO. “Our new approach, initially targeted at the field of proteomics, aims to provide faster methods and greater coverage, achieving speed, specificity and sensitivity without compromise.”
Daniel Debord“We’re thrilled to be partnering with MOBILion,” said Dr. Roberts, MOBILion’s Chief Technology Officer and lead author of the white paper. Spectroscopic analysis (MS/HRMS) approaches use quadrupole filters that analyze only one or a few analytes at a time and discard the rest. MOBILion’s new approach, called Parallel Accumulation with Mobility Aligned Fragmentation (PAMAF), removes the inherently slow and inefficient quadrupole from the workflow and replaces it with HRIM separation. The result is fragmented data that is 5x faster and has a 10x higher signal-to-noise ratio than any other method. other existing systems. I’m particularly excited to see the impact this development will have on multi-omics applications. In multi-omics applications, faster and more sensitive MS/MS shows a clear correlation with the range and number of compounds that can be detected. This has the potential to address some of the biggest challenges in drug discovery and disease research. As stated in white paperFor personalized medicine approaches, it is a dream come true for diagnostics by enabling scientists to successfully identify more proteins, lipids, metabolites, and other analytes at lower concentrations from complex samples in a shorter period of time. It could be a game-changing difference. ”
Unlike traditional MS/MS, which trades analytical sensitivity for the number of target analytes, PAMAF allows simultaneous processing of all precursors without sacrificing the sensitivity inherent in traditional quadrupole separations. . Additionally, by eliminating traditional quadrupole filters, PAMAF allows for the following compared to traditional approaches:
- Analyze more samples in less time
Researchers can now accelerate workflows and significantly increase throughput for large-scale studies without compromising data quality. The new methodology exceeds current industry standards by producing fragmented spectra at rates of up to 1,000 Hz, compared to the 200 Hz offered by current state-of-the-art HRMS systems, resulting in more fragmented spectra being analyzed per day. 2 to 5 times more samples. - Detection of trace signals in complex samples
Scientists working with difficult matrices such as body fluids can now detect important low-abundance signals that were previously undetectable. The new approach advances single analysis by achieving nearly 100% ion utilization efficiency, increasing sensitivity by orders of magnitude over traditional methods that often capture only 0.5% of the available ion signal. as well as improve the sensitivity of tissue and plasma proteomics. Cell proteomics. - Reduce ambiguity and increase confidence
Researchers studying complex biomolecules, such as proteins and metabolites, benefit from reduced ambiguity and increased confidence in their results, making it easier for researchers to discover disease biomarkers and develop therapeutics. leads to a definitive conclusion. The PAMAF approach ensures accurate handling of the “known unknowns” in proteomics, lipidomics, and metabolomics research by achieving superior separation of isobaric and isomeric compounds through HRIM technology.
Sherman continued, “Major changes in the fundamental mode of operation and platform for mass spectrometry are rare, and the implementation of our proprietary technology in this mode of operation will continue to drive mass spectrometry product development over the next 15 to 20 years. We believe it marks the beginning of MOBIE’s technology, which fundamentally reimagines the way ions are processed, separated, and analyzed, and promises unprecedented performance in speed, sensitivity, and specificity. The device was just the beginning of demonstrating the power of platform SLIM technology. This new approach is a game-changing advance with far-reaching implications for proteomics research, previously impractical or impractical due to technical limitations. It could open up new types of experiments and insights that were previously possible.”
For more information about these new features and proof-of-concept data, please see the white paper titled .Abandoning the quadrupole for mass spectrometry fragmentation analysis”
About MOBILion Systems, Inc.
MOBILion Systems is Revealing What Others Leave Unseen® pioneering the next generation of separation science by developing tools to more deeply, accurately and efficiently characterize complex molecules and samples. MOBILion is driving advances in a variety of industries, from biopharmaceutical discovery to food testing and environmental safety, with instruments that provide greater resolution than existing approaches. The company’s technology seamlessly integrates with mass spectrometry for workflows that unravel complex analyses. MOBILion is changing the paradigm of what’s possible, and we’re just getting started. Learn more here www.mobilionsystems.com.
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