Orthopedic researchers have developed a promising new nano -particle hydrogel that can be directly injected into bones that are weakened by osteoporosis. In the research recently released in the journal boneExperts say that their new solutions can help patients resist potentially deadly osteoporosis fractures.
osteoporosis Ultimately, it is an incurable disease that affects the estimated women’s estimated 50 % and 25 % of men over the age of 50. It often causes osteoporosis fractures, which can cause major long -term complications, which are fatal. However, existing medication regimens will reduce the old bone absorption rate or support new bone generation, but these treatments may take a year before providing concrete results.
“If there are no effective precautions, about 40 % of women over the age of 50 will suffer at least one large osteoporosis fracture. Men are Switzerland’s Ecole Police Politech Fedenic Federare de Lausanne. Dominke Pioletti, the head of the EPFL) Bio and Mechanical Orthopedic Institute, and Dominke Pioletti, a co -author of research, said: Accompanied statement on tuesday.
Pioletti added that many people who experienced osteoporosis fractures do not always know how serious their injuries were. For example, elderly patients face 20 % of mortality within one year after destroying the femoral bone near the waist. More than half of the same population are not completely healed by injuries.
In cooperation with the EPFL startup developed by the Pioletti team FlowboneDirectly handle the potential fracture site. Most localized options take a paste that sticks to materials like reinforcements. However, this new treatment depends on the hydrogel made from hydroxy acid and hydroxia Patite nano particles, imitating minerals that occur in the natural bone.
In the laboratory test, researchers injected hydrogel into osteoporosis rats. In just a few weeks, experts saw that the local bone density increased by 2-3 times by using the hydrogel alone. Combined with general anti -catabolic drug Zodronate, the bone density of the injection site increased by 4.8 times in just 2-4 weeks.
Hydrogel injection is not all treatments, and does not necessarily provide permanent solutions for weakening local bones. Nevertheless, combining it with existing treatments may help you speed up your patient rescue and recovery efforts.
“Our discovery is that in injections with local anti -catabolic drugs, the treatment of systemic anti -cotabolic, that is, systemic assimilation treatment that increases bones by rapidly increasing local bone density. Pioretti suggests what you can do. “
The Pioletti team and Flowbone want to start a clinical human test after moving forward, receiving approval of regulatory authorities.
“Then, we want to develop a treatment to prevent fractures due to osteoporosis based on this evidence,” he said.