Your body is a highly complex and coordinated community of interconnected organs, cells, and signaling molecules. Each part of this collaborative community works smoothly to protect you more than your immune system. This sophisticated system protects you greatly, but sometimes the immune system can become unbalanced and cause significant damage. One such response by an unbalanced immune system is the proliferation of mast cells. Mast cells misbehave, causing a serious condition called mast cell activation syndrome (MCAS), also known as mast cell disease. In this condition, mast cells are encouraged to release many inappropriate chemicals into the body, causing allergic symptoms such as hives, rashes, and swelling. If you recently experienced an allergic reaction and want to know “How I Cure Mast Cell Disease”, this article will help you. Take a thorough look to understand what MCAS is, its associated symptoms, causes, and treatments. read!
What is Mast Cell Activation Syndrome?
What is MCAS disease? It is a condition caused by irregular or overactive mast cells. Mast cell activation syndrome (MCAS) is often confused with another term known as mastocytosis. Although both fall under the mast cell disease category, they are very different conditions. What is mastocytosis? It is a rare disease in which immune cells called mast cells accumulate in excess in the liver, intestines, bones, gastrointestinal tract, and under the skin. The disease is caused by genetic changes that cause mast cells to grow abnormally, overwhelming the body and causing health problems. These include skin growths and leukemia, a type of blood cancer. So, what is mast cell activation syndrome? This condition does not include the accumulation of extra mast cells in the body’s organs and cells. Instead, it occurs when mast cells release an inappropriate number of chemicals called histamine into the body that cause allergic symptoms.
What are mast cells?
You may have never heard the term mast cell before, but mast cells are white blood cells that are found in all areas of the body. Humans are made up of excess mast cells in areas of the body that are in high harmony with the environment, such as the lungs, intestinal tract, and skin. So what do mast cells do? In general, mast cells play an important role in the immune system. When these cells detect a virus or harmful bacteria, they release a chemical known as histamine, causing an allergic reaction. This sudden response helps protect the body by fighting off infections and bacteria. In addition to this, mast cells also contribute to other important body processes such as bone growth, wound healing, and the growth of new blood vessels.
Causes of mast cell activation syndrome
What causes Mast Cell Activation Syndrome? Mast Cell Activation Syndrome is thought to be caused by changes in a gene called . transmembrane tyrosine kinase (KIT), known as a mast cell regulator. the study showed that patients with systemic MCAS have multiple or complex mutations in mRNA sequences involved in encoding transmembrane tyrosine kinase genes.another study They say the cause of MCAS may be familial, but further analysis is needed to find out if it is genetic. Certain factors can cause mast cell disease, including:
- Friction or rubbing of the skin.
- physical activity and exercise.
- Being stung by a bee, wasp, or insect.
- certain drugs such as alcohol, muscle relaxants, NSAIDs, narcotics, and some types of foods.
- Sudden temperature changes.
- physical or mental stress.
- Environmental odors or aromas.
Symptoms of mast cell activation syndrome
Some symptoms of mast cell activation affect many body systems at once. You can experience them in a variety of events, such as after taking certain medications, eating food, exercising, and smelling smells or scents. The main signs and symptoms are:
- skin swelling, rash, itching
- Fast heart rate and low blood pressure
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Abdominal pain, inflammation, chronic pain
- constipation, nausea, diarrhea
- Difficulty breathing, coughing, shortness of breath
- Headache, foggy head, dizziness
- Weakness, muscle pain, joint pain
- Allergic reactions to various triggers
- weight loss, fever, night sweats
- anxiety and depression
- fatigue and malaise
- memory and concentration problems
- Sleeping disorder
Symptoms may appear differently in each person. If symptoms persist, it is recommended to seek professional help immediately. Search online for “mast cell specialists near me” and you’ll find some of the top-listed providers in your area. A qualified and skilled doctor will diagnose the root cause and provide an effective solution.
How did you cure mast cell disease?
Looking for treatment for Mast Cell Activation Syndrome? Mast Cell Activation Disorder is incurable, but with some strategies your healthcare provider can help manage potential symptoms and complications. Doctors first perform a physical exam to diagnose mast cell disease. Rub the infected area of the skin to see if the skin is red, itchy, or inflamed. If you suffer from mast cell activation syndrome, you may experience an allergic reaction caused by the rapid and sudden release of mediators from powerful mast cells. When you browse the internet, you can see the faces of patients battling early stage mast cell disease and learn what it’s like. If you have similar symptoms, contact your health care professional immediately. Your doctor will first provide you with an epinephrine auto-injector and may refer you to an emergency room or hospital for further treatment. Doctors may also recommend drug treatment to stop mast cell reactivity. These drugs include:
- H1 blocker and H2 blocker antihistamines.
- Leukotriene inhibitors such as zafirlukast and montelukast.
- Mast cell stabilizers such as cromolyn sodium, bioflavonoids, and ketotifen.
- Aspirin is blended with a histamine blocker.
- Chemotherapy may be recommended for progressive mast cell disorders.
Adults with mast cell disease can take medications to prevent symptoms before they develop.by F.D.A., Avapritinib is approved for the treatment of progressive systemic mastocytosis. It is taken orally as a capsule. The drug provides benefits by delivering a small molecule that binds to her KIT D816V, a protein that causes abnormal mast cell proliferation. It blocks the production of histamine, which contributes to allergic reactions. Speak with a licensed health care provider to discuss medications that are right for you.
Home remedies for mast cell activation syndrome
In addition to drug therapy, mast cell activation syndrome can be prevented by avoiding factors that can potentially cause symptoms. Here are some home remedies to help manage MCAS.
Eat low histamine foods
Histamine is a mediator released by mast cells when activated by certain triggers. During these disorders, cells become overactive, resulting in high histamine levels in the body. Increased histamine can cause digestive problems, skin rashes, hives, swelling, low blood pressure, and a runny nose. In this situation, a mast cell activating diet consisting of low histamine foods comes to the rescue, reducing the total amount of histamine available from certain foods. Low-histamine foods include fresh, unprocessed whole foods such as broccoli, blueberries, peaches, sweet potatoes, pumpkin, asparagus, cucumbers, and apples. Avoid foods high in histamine, such as canned fish, fermented foods, processed cheese, soy sauce, yeast, alcohol, nuts, yogurt, and chocolate.
Also read: Low histamine diet: foods to eat and foods to avoid!
improve gut health
study It is said that approximately 70% to 80% of the body’s immune cells live in the intestines. If your mast cell disease is more severe, you may have an underlying gut health problem. These problems can occur due to certain parasite attacks, dysbiosis, leaky gut, candida overgrowth, or infections with other viruses or bacteria. In addition to stimulating the immune response, preventing intestinal problems can also reduce MCAS symptoms. The DAO enzyme, which plays an important role in histamine metabolism, is present in the intestine. Therefore, maintaining gut health is essential. Poor intestinal function can interfere with the activity of these enzymes, leading to high histamine levels.
reduce toxicity
When dealing with mast cell activation syndrome, immune cells respond markedly to stressors and perceived danger. Toxins in the body are the most significant stressors and are so largely hidden that you don’t know anything about them. They can cause cells to react dangerously or stimulate the release of large amounts of histamine levels. The less toxins you have in your body, the less likely you are to react. Therefore, to control the immune response and reduce MCAS symptoms, it is necessary to ensure a less toxic environment for healing. This practice involves eliminating all toxic products, such as household cleaners and chemical-laden beauty products, and replacing them with natural alternatives to eliminate exposure to toxic substances.
Add natural antihistamines to your diet
If you are looking to avoid Benadryl or EpiPen auto-injectors and are looking for home remedies to prevent MCAS, natural antihistamines found in herbs and foods are an ideal option. Quercetin is a natural antihistamine that can be obtained from foods such as berries, onions, broccoli, leafy greens, and apples. Quercetin supplements are also effective. Nettle is also a good choice.According to someone the study, nettle extract inhibits histamine production and relieves MCAS symptoms.another study Similar to allergy medications such as cetirizine, butterbur has been shown to be able to effectively reduce histamine levels. Triphala also works wonders as an antihistamine, anti-inflammatory, and antioxidant herb. Helps prevent histamine production and lung inflammation. This makes it an excellent option for mast cell disease patients who also suffer from reactive airway disease or allergic asthma.
summary
Mast cell activation syndrome (MCAS) occurs when mast cells repeatedly release excessive numbers of mediators in response to specific triggers. This causes the severe allergic reactions experienced by MCAS patients, including the rash, hives, itching, and swelling. Symptoms vary from person to person. There is currently no effective treatment, but certain medications and treatments can help manage these symptoms. Home remedies such as a low-histamine diet, lowering toxicity levels, reducing stress, improving gut health, and natural antihistamines can also be beneficial. This is how I cured mast cell disease. If you notice symptoms of MCAS, seek professional help immediately. If you delay, your health may deteriorate.
